Our Abnormal Chromosomes

A case of canine fibrosarcoma with abnormal chromosomes.

Automation of Identifying Abnormal Chromosomes in M-FISH

Chromosome analysis is one of the most essential tasks in clinical research of cell genetics and genetic disease diagnosis. Automatic analysis of chromosomes by computers is very useful but there are many issues yet to address. Karyotyping identifies and displays chromosomes in a standard format. In this paper, a tool has been introduced that identifies abnormal chromosomes. The tool is able to...

Normal and abnormal interchanges between the human X and Y chromosomes.

A single obligatory recombination event takes place at male meiosis in the tips of the X- and Y-chromosome short arms (i.e. the pseudoautosomal region). The crossover point is at variable locations and thus allows recombination mapping of the pseudoautosomal loci along a gradient of sex linkage. Recombination at male meiosis in the terminal regions of the short arms of the X and Y chromosomes i...

Prenatal diagnosis of extrastructurally abnormal chromosomes: clinical experience and literature review.

BACKGROUND To evaluate the clinical association of extrastructurally abnormal chromosomes (ESACs) with pregnancy outcome based on the cytogenetic characteristics of the ESACs. METHODS We retrospectively reviewed 12 ESAC cases identified from 12,991 cases who received genetic amniocentesis between January 1983 and March 2008. Prenatal ultrasound findings, characteristics of ESACs (karyotypes, ...

Abnormal length of the small acrocentric chromosomes in chronic lymphocytic leukemia.